RECOMBINANT HUMAN NAGLU PROTEIN AND USES THEREOF

专利名称：RECOMBINANT HUMAN NAGLU PROTEIN

AND USES THEREOF

发明人：QUINN, ANTHONY,LEAVITT, MARKLEY,

C.,XIA, ZHINAN,RUTKOWSKI, JOSEPH,VICTOR

申请号：EP12840612申请日：20121011公开号：EP27677A4公开日：20150715

摘要：The present invention provides compositions comprising an isolated mixture ofrecombinant human NaGlu proteins in which a substantial amount of the NaGlu proteinsin the mixture has increased levels of phosphorylated mannose that confer the proteinsto be efficiently internalized into human cells. The present invention also providesmethods of producing such mixture of NaGlu proteins, vectors used in transgenesis andexpression, host cells harboring such vectors, and methods of isolating and purifying themixture of NaGlu proteins. The invention further provides methods of treating NaGluassociated diseases.

申请人：SYNAGEVA BIOPHARMA CORP.

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