Rapid Acting Insulin Analogues

专利名称：Rapid Acting Insulin Analogues发明人：Helle Birk Olsen,Thomas Børglum

Kjeldsen,Per Balschmidt,Tine Glendorf,SvendHavelund

申请号：US12673226申请日：20080812

公开号：US20110021423A1公开日：20110127

摘要：The invention is related to fast acting insulin analogues which can form solublemix-tures (pre-mixed or self-mixed) with long acting insulin analogues. The fast action isachieved through monomerizing substitutions/deletions in the C-terminus of the B-chainof human insulin and the mixability with long acting insulin analogues is achieved througha substitution of the Zn-binding His in position B10 of human insulin with a Gln amino acidresidue. In one embodiment the invention is related to fast acting insulin analogues inwhich at least one of the natural amino acid residues in position B22-B30 in the human B-chain has been substituted with another amino acid residue having the effect ofpromoting formation of the monomeric form of insulin, the His amino acid residue inposition 10 in the B-chain is substituted with a Gln and wherein further one or more of theamino acid residues in position B22-B30 optionally have been deleted.

申请人：Helle Birk Olsen,Thomas Børglum Kjeldsen,Per Balschmidt,TineGlendorf,Svend Havelund

地址：Allerod DK,Virum DK,Horsholm DK,Lyngby DK,Bagsvaerd DK

国籍：DK,DK,DK,DK,DK

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