Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Cladribine4291-63-8HY-13599285.69C10H12ClN5O3>98%Solubility:DMSO 60 mg/mL; Water <1 mg/mLMechanisms: Pathways:Metabolism/Protease; Target:Adenosine Deaminase gyBiological Activity:Cladribine is an adenosine deaminase inhibitor used to treat hairy cell leukemia and multiplesclerosis. Target: Adenosine Deaminase Cladribine possesses concentration-dependent apoptosis-inducing potential in the HSB2 cells.Cladribine inhibits growth of primary mast cell (MC) and the MC line HMC-1 in a dose-dependentmanner, with lower IC50 values recorded in HMC-1.2 cells harboring KIT D816V compared to HMC-1.1 cells lacking KIT D816V. Cladribine (0.7-3.5 mM) and/or diltiazem (2.4 mM), is injectedintraperitoneally into adult zebrafish and red blood cell (RBC) lysates are assayed by HPLC forpy()yyylevels of purine nucleotides (e.g. ATP), potential biomarkers of cardiovascular health. Diltiazemincreased RBC ATP concentrations, which are inhibited by co-injection of cladribine....References:[1]. Guchelaar, H.J., et al., Apoptosis- and necrosis-inducing potential of cladribine, cytarabine,cisplatin, and 5-fluorouracil in vitro: a quantitative pharmacodynamic model. Cancer ChemotherPharmacol, 1998. 42(1): p. 77-83. [2]. Bohm, A., et al., In vitro and in vivo growth-inhibitory effects of cladribine on neoplastic mast[]gypcells exhibiting the imatinib-resistant KIT mutation D816V. Exp Hematol, 2010. 38(9): p. 744-55. [3]. Klein, L.C., P.K. Yeung, and J.N. Berman, Cladribine inhibits a diltiazem-induced increase in redblood cell purine nucleotide concentrations in a zebrafish model. Biomarkers, 2009. 14(8): p. 5-9. Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com 18 Wilkinson Way, Princeton, NJ 080,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr
