Inhibitors of formation of protease resistant prio

专利名称：Inhibitors of formation of protease resistant

prion protein

发明人：Bruce W. Chesebro,Byron W. Caughey,Joelle

Chabry,Suzette Priola

申请号：US09823494申请日：20010330

公开号：US20010041790A1公开日：20011115

摘要：Peptides are disclosed that inhibit the conversion of protease sensitive prionprotein (PrPsen) to the protease resistant isoform (PrPres). These peptides comprisediscrete fragments of prion proteins, and are shown to inhibit the in vitro conversion ofPrPsen to PrPres in a cell-free system. Numerous peptides are disclosed that include atleast two amino acid residues from the highly amyloidogenic region P-of the PrP protein.None of these peptides conferred protease-resistance to the PrPsen molecules. Thepresence of residues and from the highly hydrophobic sequence AGAAAAGA (position to) produced a particular inhibitory effect. The inhibition occurred with a high degree ofspecificity (e.g. with an ICof less than about 1000 M).

申请人：GOVERNMENT OF THE U.S. OF AMERICA, SECRETARY OF THE DEPARTMENTOF HEALTH AND HUMAN SERVICES

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