VISCOSITY MODULATING SUBSTANCE AND USE THEREOF

专利名称：VISCOSITY MODULATING SUBSTANCE AND

USE THEREOF

发明人：MANION, Carl, V.申请号：EP00963682.0申请日：20000921公开号：EP1218024A2公开日：20020703

摘要：It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester(APM) lowers whole blood viscosity in patients, including those suffering from sickle celldisease and plasma cell dyscrasias. Upon in vivo APM treatment, patients experienced asignificant lowering of whole blood viscosity. In vitro addition of APM to patients sampleshaving elevated whole blood viscosity resulted in reduced viscosity over time. These invitro and in vivo results identify APM as a therapeutic agent for molecular diseases whichlead to elevated whole blood viscosity. A method by which APM treatment can bemonitored is also disclosed.

申请人：Oklahoma Medical Research Foundation

地址：825 N.E. 13th Street Oklahoma CityOklahoma 73104 US

国籍：US

代理机构：UEXKÜLL & STOLBERG

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