Computer-assisted analysis

专利名称：Computer-assisted analysis

发明人：Steven J. Altschuler,Lani Wu,Michael D. Slack申请号：US11271215申请日：20051111

公开号：US200601236A1公开日：20060713

摘要：The present invention provides methods and systems for automatedmorphological analysis of cells also known as phenotypic screening. The inventivemethods are particularly useful in the rapid analysis of cells required in a biologicalscreen or in the screening for agents with a particular mechanism of action. Agents whichcause a particular phenotype in the cells can be identified using the inventive quantitativemorphometric analysis of cells. The data gathered using the inventive method can also bequantified and analyzed later for various trends and classifications (e.g., Kolmogorov-Smirnov statistics, titration-invariant similarity scores). Characteristics of cells which can bedetermined using this method include number of nuclei, size of cell, size of nuclei,number of the centrosomes, shape of cells, size of centrosomes, perimeter of nucleus,shape of nucleus, staining for a particular protein, staining for an organelle, pattern ofstaining, and degree of staining.

申请人：Steven J. Altschuler,Lani Wu,Michael D. Slack

地址：Dallas TX US,Dallas TX US,Dallas TX US

国籍：US,US,US

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