Ganglioside analogs

专利名称：Ganglioside analogs

发明人：HANS GORAN MAGNUSSON,KUMAR RAY

ASIM

申请号：AU2942892申请日：19921111公开号：AU674293B2公开日：19961219

摘要：PCT No. PCT/DK92/00333 Sec. 371 Date Sep. 12, 1994 Sec. 102(e) Date Sep. 12,1994 PCT Filed Nov. 11, 1992 PCT Pub. No. WO93/10134 PCT Pub. Date May 27,1993Ganglioside lactam analogue derivatives of general formula (I) in which A is a sialicacid residue of formula (II) which is bound via the dashed line in the 2-position; and inwhich Z1 is -OH or a group -NHX1, and Y30 is -CH3 or -CH2OH; X1 and Y1 together forma bond and Y2 is -OH or a group OR20, or X1 and Y2 together form a bond and Y1 is -OHor -NHAc; Y3 is -OH or a group -OR20; R1 is H or a sialic acid residue of formula (III) whichis bound via the dashed line in the 2-position; and in which Z2 is -OH or a group -NHX2,and Y30 is as defined above; X2 and Y10 together form a bond and Y20 is -OH, or X2 andY20 together form a bond and Y10 is -OH; with the provisos that when R1 is H, then Z1 is-NHX1, and that when R1 is a sialic acid residue of formula (III), then at least one of Z1and Z2 is different from -OH; R10 is H, a carrier CA, or a group -(Sugar)n. The compoundsare hydrolytically stable lactam analogs which spatially closely resemble the naturallyoccurring ganglioside lactones and are antigenic and able to induce the production ofantibodies that cross-react with the corresponding ganglioside lactone.

申请人：SYMBICOM AKTIEBOLAG

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