METHOD OF MAKING CAMPTOTHECIN AND CAMPTOTHECIN ANA

专利名称：METHOD OF MAKING CAMPTOTHECIN AND

CAMPTOTHECIN ANALOGS

发明人：COMINS, Daniel, L.,BAEVSKY, Matthew, F.申请号：EP92903792.7申请日：19911218公开号：EP0565621B1公开日：20000705

摘要：we produce compounds of formula (i) according to the following formula: (ii) (iii)(iv) - > - > (i) in which r may represent lower alkyl; r1 is h, lower alkyl, can be lower, alkoxyor halo; r2, r3, r4 and r5 represent each independently h, amin a lower alkyl, alkoxy,hydroxy, lower alkylthio, di (lower alkyl) amino, cyano, lowermethylenedioxy, formyl,trifluoromethyl, nitro, halo, aminomethyl, azido, amido, hydrazino, or any of the 20standard amino acids associated with the cycle of the atom, amino nitrogen; y is h, ahalogen, and x and w are.the invention also relates to processes for production of thestarting materials to the pattern given above, as well as novel intermediates used in suchprocesses.

申请人：UNIV NORTH CAROLINA STATE

地址：US

国籍：US

代理机构：Horner, Martin Grenville

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