DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS

专利名称：DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OFTHE 2 ADRENERGIC RECEPTOR

发明人：BACH TANA, Jordi,CRESPO CRESPO, Maria

Isabel,PUIG DURAN, Carlos,GUAL ROIG,Silvia,ORTEGA MUÑOZ, Alberto

申请号：EP07819060.0申请日：20071017公开号：EP2057122B1公开日：20100901

摘要：The present invention provides a Compound of formula (I), wherein: R1 is agroup selected from -CH2OH,-NH(CO)H; and R2 is a hydrogen atom; or R1 together withR2 form the group -NH-C(O)-CH=CH-, wherein the nitrogen atom is bound to the carbonatom in the phenyl ring holding R1 and the carbon atom is bound to the carbon atom inthe phenyl ring holding R2; R3a and R3b are independently selected from the groupconsisting of hydrogen atoms and C1-4 alkyl groups; X and Y are independently selectedfrom the group consisting of direct bond and oxygen atom; n, m and q each

independently has a value selected from 0, 1, 2 and 3; p has a value selected from 1, 2 and3; R4 and R5 are independently selected from hydrogen atoms, halogen atoms, C1-4alkyl, C1-4 alkoxy, -CONH2, -NHCONH2, -SR7, -SOR7, -SO2R7, -SO2NHR8 and the groups(a) and (b), wherein R7 is selected from C1-4alkyl and C3-8 cycloalkyl and R8 is selectedfrom hydrogen atoms and C1-4alkyl groups; R6 is selected from the group consisting ofhydrogen atoms, halogen atoms, C1-4 alkyl and C1-4 alkoxy or a pharmaceutically-

acceptable salt, solvate or stereoisomer thereof.

申请人：ALMIRALL, S.A.

代理机构：Srinivasan, Ravi Chandran

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